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KMID : 0922220020020020092
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Journal of the Korean Musculoskeletal Transplantation Society
2002 Volume.2 No. 2 p.92 ~ p.105
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Effects of Several Nerve Conduits for Regeneration of Wide Sciatic Nerve Gap in Rabbits
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Rhee Seung-Koo
Kang Yong-Koo
Chung Jin-Wha
Lee Sang-Wook
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Abstract
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The experiments here assessed the chronologic influence for 9 weeks after the autogenous nerve graft, vein graft, degenerated skeletal muscle graft which was denatured by deep freezing and thawing in hypotonic solution, and Goretex tube interposition, on axonal growth for the sciatic nerve gap of 10 mm in each 15 rabbits, and surveyed whether degenerated muscle or vein interposition able to serve as a nerve conduit better than autogenous nerve graft clinically.
The results were as follows : 1. Nerve conduction velocity was measured to 43.37±15.76 m/sec in normal sciatic nerve, but it was decreased at the 9th week of experiment by 10.80±4.14 m/sec in nerve graft group, 8.17±1.10 m/sec in vein graft group, 9.27±3.11 m/sec in Goretex tube inserted group, and 9.91±2.17 m/sec in degenerated muscle graft group. 2. Total numbers of regenerated myelinated axons were 4,608±82/mm2 in nerve graft group, 3,416±87/mm2 in vein graft group, 3,568±137/mm2 in degenerated muscle graft group and 3,213±43/mm2 in Goretex tube inserted group at the end of experiment. 3. The number of axons are decreased in nerve graft group than normal because of nerve degeneration by blood insufficiency. No neuromas at the nerve endings were formed in vein and Goretex tube graft groups suggesting having a good cuffing effect, but the number of axons are less than autogenous nerve graft group. In degenerated muscle graft group, the numbers of axons in both groups are less than normal but much more than vein and Goretexs tube inserted groups. Conclusively, nerve repair using degenerated skeletal muscle or vein graft could be employed as one of favorable nerve conduit, but as a second choice after the autogenous nerve graft.
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KEYWORD
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Nerve conduit, Nerve gap, Nerve graft, Vein graft, Degenerated skeletal muscle graft, Goretex tube
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